Vidal, P.M.; Karadimas, S.K.; Ulndreaj, A.; Laliberte, A.M.; Tetreault, L.; Forner, S.; Wang, J.; Foltz, W.D.; Fehlings, M.G. (2017). Delayed decompression exacerbates ischemia-reperfusion injury in cervical compressive myelopathy. JCI Insights, 2(11), e92512.


Tatenhorst, L.; Eckermann, K.; Dambeck, V.; Fonseca-Ornelas, L.; Walle, H.; Lopes da Fonseca, T.; Koch, J.C.; Becker, S.; Tonges, L.; Bahr, M.; Outeiro, T.F.; Zweckstetter, M.; Lingor, P. (2016). Fasudil attenuates aggregation of a α-synuclein in models of Parkinson’s disease. Acta Neuropathologica Communications, 22, 4-39.


Hayakawa, K.; Uchida, S.; Ogata, T.; Tanaka, S.; Kataoka, K.; Itaka, K. (2015). Intrathecal injection of a therapeutic gene-containing polyplex to treat spinal cord injury. Journal of Controlled Release, 197, 1-9.

Hodgkinson, V.L.; Dale, J.M.; Garcia, M.L.; Weisman, G.A.; Lee, J.; Gitlin, J.D.; Petris, M.J. (2015). X-linked spinal muscular atrophy in mice caused by autonomous loss of ATP7A in the motor neuron. The Journal of Pathology, doi: 10.1002/path.4511

Stelt, I. van der; Hoek-van den Hil, E.; Swarts, H.J.M.; Vervoort, J.J.M.; Hoving, L.; Skaltsounis, L.; Lemonakis, N.; Andreadou, I.; Schothorst, E.M. van. (2015). Nutraceutical oleuropein supplementation prevents high fat diet-induced adiposity in mice. Journal of Functional Foods, 14, 702-715.

Yoo, S.-W.; Motari, M.G.; Susuki, K.; Prendergast, J.; Mountney, A.; Hurtado, A.; Schnaar, R.L. (2015). Sialylation regulates brain structure and function. The FASEB Journal, gj.15-270983.

Zhou, M.; Zhang, W.; Chang, J.; Wang, J.; Zheng, W.; Yang, Y.; Wen, P.; Xiao, H. (2015). Gait analysis in three different 6-hydroxydopamine rat models of Parkinson’s disease. Neuroscience Letters, 584, 184-189.


Boehmerle, W.; Huehnchen, P.; Peruzzaro, S.; Balkaya, M.; Endres, M. (2014). Electrophysiological, behavioral and histological characterization of paclitaxel, cisplatin, vincristine and bortezomib-induced neuropathy in C57Bl/6 mice. Scientific Reports, 4, 6370.

Chen, Y.J.; Cheng, F.C.; Sheu, M.L.; Su, H.L.; Chen, C.J.; Sheehan, J.; Pan, H.C. (2014). Detection of subtle neurological alterations by the CatWalk XT gait system. Journal of Neuroengineering and Rehabilitation, 11, 62.

Hou, J.; Nelson, R.; Nissim, N.; Parmer, R.; Thompson, F.J.; Bose, P. (2014). Effect of combined treadmill training and magnetic stimulation on spasticity and gait impairments following cervical spinal cord injury (C-SCI). Journal of Neurotrauma, doi: 10.1089/neu.2013.3096.

Ishikawa, G.; Nagakura, Y.; Takeshita, N.; Shimizu, Y. (2014). Efficacy of drugs with different mechanisms of action in relieving spontaneous pain at rest and during movement in a rat model of osteoarthritis. European Journal of Pharmacology, 738, 111-117.

Madinier, A.; Quattromani, M.J.; Sjolund, C.; Ruscher, K.; Wieloch, T. (2014). Enriched housing enhances recovery of limb placement ability and reduces aggrecan-containing perineuronal nets in the rat somatosensory cortex after experimental stroke. PLoS ONE, 9(3), e93121.

Morellini, N.; Grehl, S.; Tang, A.; Rodger, J.; Mariani, J.; Lohof, A.M.; Sherrard, R.M. (2014). What does low-intensity rTMS do to the cerebellum? Cerebellum, doi:10.1007/s12311-014-0617-9.

Plucinska, K.; Crouch, B.; Koss, D.; Robinson, L.; Siebrecht, M.; Riedel, G.; Platt, B. (2014). Knock0in of human BACE1 cleaves murine APP and reiterates Alzheimer-like phenotypes. The Journal of Neuroscience, 34(32), 10710-10728.

Qin, L.; Jing, D.; Parauda, S.; Carmel, J.; Ratan, R.R.; Lee, F.S.; Cho, S. (2014). An adaptive role for BDNF Val66Met polymorphism in motor recovery in chronic stroke. The Journal of Neuroscience, 34(7), 2493-2502.

Qin, J.; Chow, S.K.H.; Guo, A.; Wong, W.N.; Leung, K.S.; Cheung, W.H. (2014). Low magnitude high frequency vibration accelerated cartilage degeneration but improved epiphyseal bone formation in anterior cruciate ligament transect induced osteoarthritis rat model. Osteoarthritis and Cartilage, 22, 1061-1067.

Rotermund, C.; Turckenmuller, F.M.; Schell, H.; Kahle, P.J. (2014). Diet-induced obesity accelerates the onset of terminal phenotypes in α-synuclein transgenic mice. Journal of Neurochemistry, doi:10-4444/jnc.12813.

Saal, K.A.; Koch, J.C.; Tatenhorst, L.; Szego, E.M.; Toledo Ribas, V.; Michel, U.; Bahr, M.; Tonges, L.; Lingor, P. AAV.shRNA-mediated downregulation of ROCK2 attenuates degerenation of dopaminergic neurons in toxin-induced models of Parkinson’s disease in vitro and in vivo. Neurobiology of Disease, doi:10.1016/j.nbd.2014.09.013.

Salvi, J.; Bertaso, F.; Mausset-Bonnefont, A.L.; Metz, A.; Lemmers, C.; Ango, F.; Fagni, F.; Lory, P.; Mezghrani, A. (2014). RNAi silencing of P/Q-type calcium channels in Purkinje neurons of adult mouse leads to episodic ataxia type 2. Neurobiology of disease, doi:10.1016/j.nbd.2014.04.005.

Tsika, E.; Kannan, M.; Shi-Yan Foo, C.; Dikeman, D.; Glauser, L.; Gellhaar, S.; Galter, D.; Knott, G.W.; Dawson, T.M.; Dawson, V.L.; Moore, D.J. (2014). Conditional expresiion of Parkinson’s disease-related R1441C LRRK2 in midbrain dopaminergic neurons in mice causes nuclear abnormalities without neurodegeneration. Neurobiology of Disease, doi:10.1016/j.nbd.2014.08.027.



単関節炎 – カラギーナンの膝関節への投与


Moller, K.A.; Berge, O.-G.; Hamers, F.P.T. (2008). Using the CatWalk method to assess weight-bearing and pain behaviour in walking rats with ankle joint monoarthritis induced by carrageenan: effects of morphine and rofecoxib. Journal of Neuroscience, 174(1), 1-9.

変形性関節症 – 膝関節へのヨウ化ナトリウム一ナトリウム(MIA)の注射

興味深いことに、OA動物の歩行解析では、歩行速度、歩幅、歩容、ストライド、スイング時間などの測定されたパラメータのうち、耐荷重を除いて変更されていないことが明らかになりました。歩行中に床に接触することを最小限に抑え、痛みの少ない四肢に圧力をかけることができるため、変形性関節症の肢に体重がかからないようにすることができます。したがって、CatWalkは、機械的異痛を推測する可能性のある体重負荷を間接的に測定することにより、OAモデルにおける侵害受容を評価するための良い試験であると思われます。また、歩行が最も重度の機械的要因を引き起こすOA患者の日常的な状況と良好な相関がある 影響を受けた脚からの体重の変化が起こる、と語られています。

Ferreira-Gomes, J.; Adaes, S.; Castro-Lopes, J.M. (2008). Assessment of movement-evoked pain in osteoarthritis by the knee-bend and CatWalk tests: a clinically relevant study. The Journal of Pain, 9(10), 945-954.

皮質脊髄路損傷 – 錐体外切開モデル


Starkey, M.L.; Barritt, A.W.; Yip, P.K.; Davies, M.; Hamers, F.P.T.; McMahon, S.B.; Bradbury, E.J. (2005). Assessing behavioural function following a pyramidotomy lesion of the corticospinal tract in adult mice. Experimental Neurology, 195(2), 524-539.

末梢神経再生 – 坐骨神経挫滅

CatWalkで視覚化したフォローアップ期間中、ラットやマウスのいずれかで印刷物を得るのに多くの圧力を必要としない写真フィルム(De Medinacelli法)で回収されたが、印刷領域は回復したシステム。”


Vogelaar, C.F.; Vrinten, D.H.; Hoekman, M.F.M.; Brakkee, J.H.; Burbach, J.P.H.; Hamers, F.P.T. (2004). Sciatic nerve regeneration in mice and rats: recovery of sensory innervation is followed by a slowly retreating neuropathic pain-like syndrome. Brain Research, 1027(1-2), 67-72.

急性疼痛 – カラギーナン誘発急性疼痛





Gabriel, A.F.; Marcus, M.A.E.; Honig, W.M.M.; Walenkamp, G.H.I.M.; Joosten, E.A.J. (2007). The CatWalk method: a detailed analysis of behavioral changes after acute inflammatory pain in the rat. Journal of Neuroscience Methods, 163(1), 9-16.

神経因性疼痛 – 慢性絞扼傷




Vrinten, D.H.; Hamers, F.F. (2003). ‘CatWalk’ automated quantitative gait analysis as a novel method to assess mechanical allodynia in the rat; a comparison with von Frey testing. Pain, 102(1-2), 203-209.

パーキンソン病 – 両側部分的6-ヒドロキシドパミン(6-OHDA)ラットモデル



Vlamings, R.; Visser-Vandewalle, V.; Koopmans, G.; Joosten, E.A.J.; Kozan, R.; Kaplan, S.; Steinbusch, H.W.M.; Temel, Y. (2007). High frequency stimulation of the subthalamic nucleus improves speed of locomotion but impairs forelimb movement in Parkinsonian rats. Neuroscience, 148(3), 815-823.

末梢神経損傷 – 坐骨神経変性(完全な神経切断)




Deumens, R.; Jaken, R.J.P.; Marcus, M.A.E.; Joosten, E.A.J. (2007). The CatWalk gait analysis in assessment of both dynamic and static gait changes after adult rat sciatic nerve resection. Journal of Neuroscience Methods, 164(1), 120-130.

末梢神経損傷 – 坐骨神経挫滅損傷モデル


Bozkurt, A.; Deumens, R.; Scheffel, J.; O’Dey, D.M.; Weis, J.; Joosten, E.A.; Fuhrmann, T.; Brook. G.A.; Pallua, N. (2008). CatWalk gait analysis in assessment of functional recovery after sciatic nerve injury. Journal of Neuroscience Methods, 173(1), 91-98.

末梢神経損傷 – 神経隙間モデル

CatWalkは、他の行動テストのパラダイムに対する補完的アプローチとして、動的および静的歩行パラメータを同時に測定することができ、臨床的に関連する行動上の利点を評価することができます。 CatWalk分析の静的パラメータ。

Lin, K.-L.; Yang, D.-Y.; Chu, I.-M.; Cheng, F.-C.; Chen, C.-J., Ho, S.-P.; Pan, H.-C. (2009). DuraSeal as a Ligature in the Anastomosis of Rat Sciatic Nerve Gap Injury. Journal of Surgical Research, article in press, doi:10.1016/j.jss.2008.10.020.

外傷性脳損傷 – CCI



Neumann, M.; Wang, Y.; Kim, S.; Hong, S.M.; Jeng, L.; Bilgen, M.; Liu Jialing. (2009). Assessing gait impairment following experimental traumatic brain injury in mice. Journal of Neuroscience Methods, 176(1), 34-44.

脊髄損傷 – 側丘咬傷


Cao, Y.; Shumsky, J.S.; Sabol, M.A.; Kushner, R.A.; Strittmatter, S.; Hamers, F.P.T.; Lee, D.H.S.; Rabacchi, S.A.; Murray, M. (2008). Nogo-66 receptor antagonist peptide (NEP1-40) administration promotes functional recovery and axonal growth after lateral funiculus injury in the adult rat. Neurorehabilitation and Neural Repair, 22(3), 262-278.

脊髄損傷 – 中程度の挫傷

BUB C1q KOは、BMSスケールに反映されていない、CatWalkで測定された歩行の細部の回復が改善されたことを示しています。これらの結果は、特定の傷害重症度に関連すると予測される赤字に敏感な行動テスト”

Galvan, M.D.; Luchetti, S.; Burgos, A.M.; Nguyen, H.X.; Hooshmand, M.J.; Hamers, F.P.T.; Anderson, A.J. (2008). Deficiency in complement C1q improves histological and functional locomotor outcome after spinal cord injury. The Journal of Neuroscience, 28(51), 13876-13888.

脊髄損傷 – 軽度および中等度の片側性挫傷


Gensel, J.C.; Tovar, C.A.; Hamers, F.P; Deibert, R.J.; Beattie, M.S.; Bresnahan, J.C. (2006). Behavioral and histological characterization of unilateral cervical spinal cord contusion injury in rats. Journal of Neurotrauma, 23(1), 36-54.

脊髄損傷 – 断裂傷

BBBスコアリング法を用いて、CSTx、RSTxおよびHx群のラットは、全期間にわたり一貫した後肢/前肢の協調を回復せず、機能回復は、病変後のディップの差を除いて、群間で有意に異ならなかった。 CSTx動物は、偽手術対照とほぼ同じ結果を示したが、RSTxおよびHx動物では、有意差は認められなかったが、対照群と比較して、CatWalk分析では、肢間協調(RI) CatWalkテストの四肢の調整。

Hendriks, W.T.J.; Eggers, R.; Ruitenberg, M.J.; Blits, B.; Hamers, F.P.T.; Verhaagen, J.; Boer, G.J. (2006). Profound differences in spontaneous long-term functional recovery after defined spinal tract lesions in the rat. Journal of Neurotrauma, 23(1), 18-35.

脊髄損傷 – 断裂傷


Klapka, N.; Hermanns, S.; Straten, G.; Masanneck, C.; Duis, S.; Hamers, F.P.T.; Muller, D.; Zuschratter, W.; Muller, H.W. (2005). Suppression of fibrous scarring in spinal cord injury of rat promotes long-distance regeneration of corticospinal tract axons, rescue of primary motoneurons in somatosensory cortex and significant functional recovery. European Journal of Neuroscience, 22(12), 3047-3058.

脊髄損傷 – 挫傷


Koopmans, G.C.; Brans, M.; Gomez-Pinilla, F.; Duis, S.; Gispen, W.H.; Torres-Aleman, I.; Joosten, E.A.J.; Hamers, F.P.T. (2006). Circulating insulin-like growth factor I and functional recovery from spinal cord injury under enriched housing conditions. European Journal of Neuroscience, 23(4), 1035-1046.